Splenic siderosis and parenteral iron dextran in maintenance haemodialysis patients.
نویسندگان
چکیده
The histological features of 40 spleens surgically removed from maintenance haemodialysis patients are reported. Twenty-four of the 40 (60%) showed massive iron loading and a significant direct correlation was found between iron loading and the amount of intravenous iron dextran administered. Since parenteral iron dextran appears to be a major factor in causing iron overload in haemodialysis patients its use as a method of iron replacement in these patients would appear inappropriate.
منابع مشابه
Economic appraisal of maintenance parenteral iron administration in treatment of anaemia in chronic haemodialysis patients.
BACKGROUND Iron deficiency is common in haemodialysis patients and adequate supplementation by the oral or parenteral route has been limited by drug side-effects, absorption, and cost. Intermittent doses of intravenous iron dextran complex are recommended in patients with inadequate iron stores despite maximal tolerated oral dose. We conducted a prospective study with economic analysis of a reg...
متن کاملMotion Sickness , Ginger , and Psychophysics
(1490-2510 ng/dl) the marrow iron score was only 2 + (nondialysis control value). 1-3 In previous studies of serum ferritin and marrow iron, no attempt was made to investigate iron overload in the liver and spleen. In the absence ofhepatosplenic siderosis the marrowiron stores can be expected to represent total-body iron stores, and iron-depleted marrow can be regarded as evidence of iron defic...
متن کاملParenteral iron dextran therapy.
Parenteral iron therapy is indicated in patients with iron-deficiency anemia associated with conditions that interfere with the ingestion or absorption of oral iron. Replacement doses of iron required to replenish iron stores are based on body weight and the observed hemoglobin value. Methods of administering iron dextran are reviewed, including intramuscular and intravenous injections of the u...
متن کاملExperimental hepatic cirrhosis in dogs caused by chronic massive iron overload.
Starting in October 1966, 19 dogs have been subjected to massive parenteral iron loading using intravenous iron-dextran and intramuscular iron-sorbitol. Although 13 animals died, in many cases the deaths were attributable to fighting. The large doses of iron employed (up to 5.8 g/kg) were well tolerated by the surviving animals, and after 35 to 47 months five of the six survivors have developed...
متن کاملSpleen size in chronic renal failure.
To investigate the cause of clinically detectable splenomegaly, which is common in patients receiving regular haemodialysis, splenic volume was assessed by isotopic scanning using intravenously injected technetium-99m microspheres in 34 controls and 149 patients with chronic renal failure. Of the patients, 16 had never received dialysis, 10 were undergoing continuous peritoneal dialysis, 94 wer...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of clinical pathology
دوره 37 1 شماره
صفحات -
تاریخ انتشار 1984